Abstract: Background: In the literature, some of the skin pustular lesions of BD resembling the pustular lesion of acne vulgaris (AV) was called acneiform lesion of BD. It was suggested that AV was seen more often in BD than in normal population. AV is a common and very frequent skin lesion. The lesions are polymorphic, and are noninflamed (closed or open comedones) or inflamed (papules, pustules, nodules). Objectives: To find if ...
Abstract: Introduction: Despite the well-established association of malignancy and autoimmune diseases, malignancy seems to be infrequent in Behcet's Disease (BD). The evidence for neoplasm in BD is derived primarily from case reports (only 19 cases in the literature). This study was designed to find the occurrence of malignant disorders in a large group of patients with BD, and their characteristics. Patients & Methods: We reviewed the medical records of all patients with ...
Abstract: Introduction: Behcet's Disease (BD) is mainly seen in the countries along the Silk Rout. Among Asian countries, there is no data from Afghanistan on the clinical features of BD. Near 2 million Afghan immigrants live in Iran. This is a report on the clinical features of the disease in them with a comparison to the Iranian patients. Patients & Methods: All Afghan patients with BD referred to our BD unit ...
Abstract: Introduction: In a preliminary report to the 8th International Congress on Behcet’s Disease (BD) in 1998, we showed the efficacy of combination therapy with low dose pulse Cyclophosphamide (LDP) and Methotrexate (MTX) in posterior uveitis (PU) and retinal vasculitis (RV) of BD. We present here our experience with more patients and a longer follow up. Patients & Methods: BD Patients who were on the association of LDP and MTX due ...
Abstract: Introduction: The diagnosis of Behcet's Disease (BD) is based on clinical criteria. Muco-cutaneous symptoms are the most important among them. Materials and Methods: From 1992 to 1999 we screened systematically all patients attending the Behcet's Disease Research Unit for muco cutaneous lesions. Only recurrent lesions were taken in consideration. Results: Mucous-membrane lesions: 1- Oral aphthosis was seen in 96.1%+ 0.6 of patients. The separation in major and minor aphthosis has no interest. ...
Abstract: Introduction: Iran is among the countries with high prevalence of Behcet's Disease (BD). The epidemiological survey on different aspects of the disease has been continuously carrying out since 1975 in our center. The aim of this study was to find if the characteristics of the disease are changing through the time. Patients & Methods: In a cohort of 4130 patients with BD, registered at our BD unit during the past 25 ...
Abstract: Introduction: In a preliminary report to the 8'" International Congress on Behcet's Disease (BD) in 1998, we showed the efficacy of combination therapy with low dose pulse Cyclophosphamide (LDP) and Methotrexate (MTX) in posterior uveitis (PU) and retinal vasculitis (RV) of BD. We present here our experience with more patients and a longer follow up. Patients & Methods: BD Patients who were on the association of LDP and MTX due to ...
Abstract: Introduction: Ocular lesions of Behcet's Disease (BD) need aggressive treatment to prevent from severe loss of vision or blindness. Cytotoxic drugs are thought to be effective, but no control study has yet been done to show their efficacy. This study was designed to evaluate the short-term efficacy of pulse cyclophosphamide (PCP) in a randomized double blind control study. Materials & methods: PCP was used as lg per square meter of body ...
Abstract: Introduction: The natural history of ocular manifestations is very poor in Behcet's Disease (BD). The lesions progress by successive attacks leading to sever loss of vision or blindness. Aggressive treatments, by the association of cytotoxic drugs and steroids, have dramatically changed the outcome. However, still some ophthalmologists are convinced that the improvement is temporary and in the long run the eyes progress toward blindness. The aim of this study was ...
Abstract: lntroduction: Ocular lesions of Behcet's Disease (BD) need aggressive treatment to prevent from severe loss of vision or blindness. Cytotoxic drugs are necessary for the treatment. A short-term study with azathioprine (AZA) was presented to the 8th lnternational Conference on Behcet's Disease. The aim of this study is to present the results for a longer period of time. Materials & methods: Patients (32) who received more than 9 months of treatment ...